Atypical Antipsychotics (Medical Psychiatry) by John C. Csernansky, John Lauriello PDF

By John C. Csernansky, John Lauriello

ISBN-10: 0203026446

ISBN-13: 9780203026441

ISBN-10: 0824754123

ISBN-13: 9780824754129

Showcasing the most recent stories within the box, this reference unveils contemporary breakthroughs within the use of peculiar antipsychotics for the remedy of numerous sufferer populations-tracking advancements within the administration of sufferers with schizophrenia and affective psychotic problems, in addition to healing regimens for kids and kids.

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J Psychiatr Res 1998; 32(3–4):215–228. 4. Roth BL, Shapiro DA. Insights into the structure and function of 5-HT2 family serotonin receptors reveal novel strategies for therapeutic target development. Exp Opin Ther Targets 2001; 5:685–695. 5. Revicki DA. Cost effectiveness of the newer atypical antipsychotics: a review of the pharmacoeconomic research evidence. Curr Opin Investig Drugs 2001; 2(1):110–117. 6. Geddes J, et al. Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis.

Schoemaker H, et al. Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity. J Pharmacol Exp Ther 1997; 280(1):83–97. 32. Karlsson P, et al. Lack of apparent antipsychotic effect of the D1-dopamine receptor antagonist SCH39166 in acutely ill schizophrenic patients. Psychopharmacology (Berl) 1995; 121(3):309–316. 33. Eder DN. CEE-03–310 CeNeS pharmaceuticals. Curr Opin Investig Drugs 2002; 3 (2):284–288. 34. Roth B, et al.

By strict pharmacological criteria, only clozapine and quetiapine (and Probing the "receptorome" unveils the receptor pharmacology 29 perhaps aripiprazole) would be classed as atypical because these are the only known medications which are devoid of EPS and do not elevate serum prolactin levels. The other atypical antipsychotic drugs either induce EPS to some extent, typically in a doserelated manner, or elevate serum prolactin levels, or both. It is also clear that drugs such as clozapine probably have unique advantages as well, since clozapine has now been demonstrated to reduce suicide among schizophrenics (7, 119, 120).

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Atypical Antipsychotics (Medical Psychiatry) by John C. Csernansky, John Lauriello


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